Hong Li, Ph.D.
Biography
Research Interests
- Proteomic studies of redox-dependent cell survival and cell death signal transduction
- Develop high-throughput mass spectrometry technologies to study the protein post-translational modifications and
- protein-protein interactions
- Develop novel proteomics methods to study the regulation of protein S-nitrosation, sulfonation and disulfide bonds in cells
Education
- Ph.D., 1997, University of Nevada
- B.S., 1992, University of Nevada
Languages
Chinese
Publications
Zhong, F., Chen, H., Azeloglu, E., Wei, C., Zhang, W., Li, Z., Chuang, Y.P., Jim, B., Li, H., Chen, H., Wang, Y., Jia, W., Lee, K. and He, C.J. (2018) Protein S Protects Against Podocyte Injury in Diabetic Nephropathy, J Am Soc Nephrol. 29(5):1397- 1410.
Wu, C., Dai, H., Yan, L., Cui, C., Liu, T., Chen, T., and Li, H. (2017) Sulfonation of the Resolving Cysteine in Human Peroxiredoxin 1: A Comprehensive Analysis by Mass Spectrometry. Free Radical Biology & Medicine. 108:785-792.
Ron, A., Azeloglu, E., Calizo, R., Hu, M., Bhattacharya, S., Chen, Y., Jayaraman, G., Lee, S., Neves-Zaph, S., Li, H., Gordon, R., He, J., Hone, J., and Iyengar, R. (2017) Cell shape information is transduced through tension- independent mechanisms. Nat Commun. 8(1):2145.
Beuve A, Wu C, Cui C, Liu T, Jain MR, Huang C, Yan L, Kholodovych V, Li H. (2016) Identification of novel S-nitrosation sites in soluble guanylyl cyclase, the nitric oxide receptor. Journal of Proteomics. 138:40-7.
Sciarretta, S., Zhai, P., Maejima, Y., Del Re, D.P., Nagarajan, N., Yee, D., Liu, T., Magnuson, M.A., Volpe, M., Frati, G., Li, H., Sadoshima, J. (2015) mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell reports. 11(1):125-36.
Wu, C., Jain, M.R., Li, Q., Oka, S., Li, W., Kong, A.N., Nagarajan, N., Sadoshima, J., Simmons, W.J., Li, H. (2014) Identification of novel nuclear targets of human thioredoxin 1. Mol & Cellular Proteomics 13(12):3507-18.
Li, H, Liu, T, Chen, W, Jain, MR, Vatner, DE, Vatner, SF, Kudej, RK, Yan, L. (2013) Proteomic Mechanisms of Cardioprotection during Mammalian Hibernation in Woodchucks, Marmota Monax. J Proteome Res. 12 (9): 4221-4229.
Ucker, D.S., Jain, M.R., Pattabiraman, G., Palasiewicz, K., Birge, R.B., and Li, H. (2012). Externalized glycolytic enzymes are novel, conserved, and early biomarkers of apoptosis. Journal of Biological Chemistry. 287(13):10325-43.
Wu C, Liu T, Chen W, Oka S, Fu C, Jain MR, Parrott AM, Baykal AT, Sadoshima J, Li H. (2010) Redox regulatory mechanism of transnitrosylation by thioredoxin. Mol Cell Proteomics. 9(10):2262-75.
Ago, T., Liu, T., Zhai, P., Chen, W., Li, H., Molkentin, J. D., Vatner, S. F., Sadoshima, J., A Redox-Dependent Pathway for Regulating Class II HDACs and Cardiac Hypertrophy. Cell. 2008, 133 , 978-993.