Paper Published in Cell Reports Showing Important Role for Adenosine

In August 2022, Darine El-Naccache published a paper in Cell Reports showing an important role for adenosine in triggering type 2 immune responses through binding the Adenosine A2b receptor expressed on intestinal epithelial cells. These studies were part of her Ph.D. dissertation research in Dr. Gause's laboratory, and the studies were done in collaboration with Dr. George Hasko at Columbia University. These findings further showed that the adenosine was derived from extracellular ATP and essentially functions as an endogenous danger signal likely triggered through tissue damage occurring as helminth parasites cross the intestinal barrier. The findings were highlighted in an article in Rutgers Today.

https://www.cell.com/cell-reports/fulltext/S2211-1247(22)00959-7